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Advantages: No medication-related side effects Cost-effective Improves overall health, including cardiovascular fitness and mental well-being Limitations: Sustaining significant weight loss can be challenging, particularly for individuals with hormonal or metabolic conditions

The most common adverse reactions that have been reported with topical azelaic acid formulations are burning, itching, stinging, dryness, and erythema which are temporary and mild (Kirsch et al., 2019

Accordingly, an allele carrying a mutation that is beneficial would be selected for amplification, and/or the corresponding WT allele might be reduced or lost (e.g

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Difficulty feeling satisfied despite eating regular portions